Fundación ONCE has a Board, which is the highest governance body of the institution, containing the main organizations of persons with disabilities in our country, such as COFEMFE, FEAPS, CNSE, FIAPAS, FEAFES and ASPACE; as well as the Spanish Committee of Representatives of Persons with Disabilities (CERMI) and the State Administration.

It has a Permanent Commission, which acts on delegation of the Board and a Management Committee.